Creatine Ketosis

It refers to the metabolic pathways in the to the liver moves and turns into glucose, which is back to the muscles and lactate lactate produced by anaerobic Glycolysis of the muscles that are metabolized. Carl Cori and Gerty CORI jointly won the Nobel Prize for Physiology or medicine, 1947 but for his discovery of the CORI cycle, but for his discovery of the course of the catalytic conversion of glycogen. The muscular activity requires ATP, comes from glycogen degradation in skeletal muscle. The breakdown of glycogen, a process known as Glycogenolysis, releases, glucose form glucose-1-phosphate (g-1 - P). G-1-P is converted into G-6-P with the enzyme phosphoglucomutase. G-6-P is easily introduced in the Glycolysis or pentose phosphate can go, if the concentration of G-6-P is a process, allows the muscle ATP as a source of energy creatine ketosis for most cells. During muscle activity, the ATP shop must be constantly renewed. When the oxygen supply is sufficient, comes this energy from the force of the pyruvate, a product of glycolysis, the Krebs cycle. If the oxygen supply, not enough usually during intense muscular activity, energy must be released by anaerobic metabolism. Lactic acid fermentation converts pyruvate, lactate by lactate dehydrogenase. Most importantly, regenerates NAD fermentation. Transfer of two electrons from NADH to reduce pyruvate to lactate. See main article Glycolysis and fermentation for details. I prefer that they accumulate in muscle cells, produced by anaerobic fermentation continued through the liver lactate. This starts the other half of the CORI cycle. Gluconeogenesis occurs in the liver. From the point of view, Gluconeogenesis intuitively had Glycolysis and fermentation in the conversion of Pyruvate to lactate before finally into glucose, vice versa. Then supplied glucose to the muscles through the bloodstream. It is ready to provide further reactions of Glycolysis. If muscle activity has ceased, the glucose is used to replenish the reserves of glycogen by Glucogenesis. Importance of the cycle is based on the prevention of lactic acidosis in the muscle under anaerobic conditions. Without however normally until it produces lactic acid in the muscles and liver. The cycle is also important in the production of ATP, source of energy for muscular work. CORI cycle functions more efficient if muscle activity has stopped. In this way, debt be repaid oxygen so that the electron transport chain and Krebs cycle can produce energy with high efficiency. The drug metformin may cause lactic acidosis in patients with renal failure, because metformin inhibits the CORI cycle. Usually excess lactate would be eliminated by the kidneys, but can in patients with kidney failure, the kidneys don't handle for excess lactic acid. This article is for the review. Please help improve this article by references to reliable sources. Promotional material can be challenged and removed. . . . . .