Bb Creatine Kinase

At the beginning of the adult PageDISCUSSIONIn, necrosis and neuronal apoptosis after global ischemia is slow and last for several hours up to several days (20). Studies in animals show perinatal faster destruction of cells (3). It is not known how long will be the window of opportunity is still open for the intervention, but any early intervention after insult (21). Energy in the neonatal brain substrates continue falling during 12 to 48 h after hypoxia (22). 2-6 h after birth can be effectively asphyxia. Detrimental measures (23) may be neuroprotective, should begin soon, brain damage or significant and reliable long-term prognosis indicators or stop to find neuroprotective therapies. Somatosensory evoked potential, of cranial of computed tomography and magnetic resonance imaging are useful for forecasting, but not the first 24 hours after birth (24, 25). Magnetic resonance spectroscopy demonstrates commitment to energy brain (6) but not in a clinical situation as you can. AEEG is a diagnostic tool for the evaluation of the encephalopathy. Previous reports (4, 5) implemented a set of postnatal aEEG precious predictive neurological. Several studies measured biochemical factors in serum and fibrillar protein in the cerebrospinal fluid acid glia after 12-48 12 to 48 hours (7); excitatory amino acid after h 18-66 (8); and IL-6-12 h after an ischemic event hypoxic (9). Urinary lactate: creatine predicted ratio (10) nuclear magnetic resonance spectroscopy was less than 6 hours to 1:0, but a little above should be an indicator useful for hypoxic-ischemic encephalopathy and requires a technical laboratory quickly and easily accessible. In addition, children often oliguria with suffocation and urine collection may not be possible (26). Our findings confirm early HIE serum NSE as an indicator. Even within 12 hours after birth in the serum concentration of NSE it didn't increase significantly in neonates with hypoxic-ischemic encephalopathy mild and moderate or severe with young children no comparison here. Other studies (16, 17) NSE managing complex results newborn serum NSE in cerebrospinal fluid and our data seems to be cheaper. These results are CK-BB, where the increase was according to studies, in the first 4-15 hours of life (13-15). Our creatine kinase BB activities were lower in Walsh et al (14) and Fernández et al (15), probably under the measurement of the kinase activity of the total creatine at different temperatures. CK-BB is expressed in the placenta, lung, estomago-intestino and kidney, only the aftermath of asphyxia may play a role. Although the placenta is rich of activities of CK-BB, seems to be its contribution to the CK-BB-serum levels with the newborn insignificant (27). Slopes (13) found that blood levels of CK-BB in newborn infants with kidney disease or estomago-intestino of the tract was not extended. Therefore, assume that more comprehensive complex administrative children mainly in the brain. Protein S-100 is also known as skeletal muscle, heart, kidneys, adipocytes and thyme exists of the newborn (28, 29). Until now, no study has examined the complex administration of serum S-100 protein and formula checks at the age. In adults the imperceptible is the protein S-100 in serum under normal conditions (30); Nevertheless in brain diseases, has varied from zero (31) a values highly predictive (32). In addition, clinical studies in terms of different times for adults to increase serum protein S-100, as the temporary increase after cardiac surgery (33), peaks in 24 hours after the bloody brain (34) or global cerebral ischemia (32) and a maximum of 3 d after an accident of acute ischaemic stroke (34, 35). Show concentrations in serum of infants related to age, S-100 protein after cardiac surgery and extracorporeal circulation was founded, the highest in infants and children with Down syndrome with a temporary increase in the model were similar in adult patients (36). Version of serum S-100 protein a model similar to the temporary increase follows cardiac post-surgery of suffocation. Suppose that, choking, high levels of loss of serum S-100 protein in extracellular fluid are caused after a membrane of neuronal and glial hypoxic with low renal excretion. The integrity of the blood barrier - brain appears to their levels in the serum, influence, that explains why the serum concentration of S-100 protein in adults than in children (36) is low. Recent studies found elevations of transition of serum protein s-100 independent neuronal damage and the question arose whether the S-100 protein comes from sources noncerebral (37, 38). We could not exclude that the S-100 protein and CK-BB-only release of the brain. It may be a General simple epiphenomenon, of asphyxia ischemia. Choking can mean the body could and caused the release of proteins in the blood a sign of changes in the integrity of the cell and membrane permeability of vascular injury of ischemic reperfusion of the whole body. In our opinion, no single diagnostic marker neuroprotective treatment should form the basis for decisions. But the decision, which could be candidates children bb creatine kinase postasphyxial, processing deficit, CK-BB and serum S-100 protein and Apgar score must probably based on numerous comments, including the aEEG, the blood of the umbilical cord, cord blood pH. These biochemical markers may be useful to determine if an early neuroprotective treatment initiated is continued or stopped. However, you will find our data from a small number of non-permanent babies, hypoxic-ischemic encephalopathy and brain damage. The development of the brain of the monitoring with our children in the coming years will be displayed if the serum protein increased S-100 and CK-BB even predictions of developmental delay. .